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Research Resources


NIH Resources

NIH Publications on Biomarkers and Surrogate Endpoints

Biomarkers Definitions Working Group (2001).  Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework. Clinical Pharmacology & Theraupeutics 69 (3): 89-95.


Featured Books


Biosocial Surveys.  2007. Prepublication copy. Committee on Advances in Collecting and Utilizing Biological Indicators and Genetic Information in Social Science Surveys, National Research Council. Maxine Weinstein, James W. Vaupel, and Kenneth W. Wachter, editors.

Aging, Health, and Public Policy. 2004. Demographic and Economic Perspectives. A supplement to Vol. 30, 2004 Population and Development Review. Linda J. Waite, editor.

Cells and Surveys: Should Biological Measures Be Included in Social Science Research? 2000. Committee on Population. National Research Council. Caleb E. Finch, James W. Vaupel, and Kevin Kinsella, editors.  Find this book on Amazon.

Manuel, D., V. Flintoft, and D. Glazer. (1999). An ICES Report: Physical Measures in Population-Based Health Surveys – Measures and Methods. Toronto: Institute for Clinical Evaluative Sciences.


Research Resources by Topic


Methodology of Biomarker Collection and Measurement

Lab Tests Online

Clinical Immunology Division (Head - Dr. Mark H. Wener) at the Department of Laboratory Medicine, University of Washington, offers a wide range of assays to aid in the diagnosis, management, and monitoring of problems associated with immunological disorders. Dr. Wener's lab adapted blood spot methods for high throughput analyses.  It now has DBS protocols for CRP, EBV ab, TC, HDL, Tri, and glucose, all of which are being done for Add Health population-based project.

Demecal (Netherlands) offers blood spot assays for population-based research.

Highly Sensitive C-Reactive Protein (HS-CRP)

Skogstrand K. et al. (2005). Simultaneous Measurement of 25 Inflammatory Markers and Neurotrophins in Neonatal Dried Blood Spots by Immunoassay with xMAP Technology. Clin Chem. 51(10):1854-66.


Ethics, confidentiality, and informed consent

Ethical and Social Issues in the Use of Biomarkers in Epidemiologic Research
by Schulte, Hunter, and Rothman

White, Mary Terrell; Gamm, Jennifer. 2002. Informed consent for research on stored blood and tissue samples: a survey of institutional review board practices. Accountability Research, 9(1): 1-16.

Wolf LE, Lo B. 2004. Untapped potential: IRB guidance for the ethical research use of stored biological materials. IRB. 26(4):1-8.

Stegmayr B, Asplund K. 2002. Informed consent for genetic research on blood stored for more than a decade: a population based study. BMJ. 325(7365):634-5.


Models and Analyses (under construction)